How did This Paper Advance the Field or Overturn Existing Paradigms?

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Endodermal origins

Tethered wingless

 

SKU: ENG000697

A.Endodermal origins (Kwon et al.)

  1. Describe the major question being asked?
  2. What was the state of knowledge before this paper?
  3. What motivated the experiments done in this paper? i.e., if a hypothesis was being tested, what led to that hypothesis? If an unexpected observation motivated the experiments, what was the observation?
  4. How did this paper advance the field or overturn existing paradigms?
  5. Why was the knowledge gained through this study important beyond telling us more details about where endoderm comes from? (i.e. why was this a Developmental Cell paper?)
  6. Do you feel that Figures 5D-F and H definitively proved that the cells that crossed the basal lamina are of epiblast origin? Why or why not? If your answer is no, how could you prove this?

B.Tethered Wingless (Alexandre et al.)

  1. Describe the major question being asked?
  2. What was the state of knowledge before this paper?
  3. What motivated the experiments done in this paper? i.e., if a hypothesis was being tested, what led to that hypothesis? If an unexpected observation motivated the experiments, what was the observation?
  4. How did this paper advance the field or overturn existing paradigms?
  5. Why was the knowledge gained through this study important beyond telling us more details about fly development? (i.e. why was this a Nature paper?)

C.For one of the two papers (your choice) answer the following questions. What do you think is the next step for this research? What hypothesis would you test, and how would you test it?

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